Benchmark Dose Software (BMDS) Development and Maintenance Toxicodiffusion Model (External Review Draft, Version 1.0)
Time-course, or repeated (response) measures, data can be utilized to characterize toxic effects that are potentially evolving along critical time points. Neurotoxicity experiments, such as neurobehavioral screening studies, often produce time-course data. It may be advantageous for dose-response assessments to consider the time impact on the potential toxic effects. Thus, a model that provides predictions of responses as a function of both dose (exposure) and time should be available to provide relevant estimates (e.g., of BMDs) when a risk assessor must rely on such data. The software under consideration here is intended to be applied to such data to model the repeated measures (over time) of a single response metric, following various levels of exposure.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
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