ECOTOX Knowledgebase

About ECOTOXAquatic life, terrestrial plants and wildlife

ECOTOX is a comprehensive Knowledgebase providing single chemical environmental toxicity data on aquatic and terrestrial species.
Read more in: Olker et al. 2022

Learn More

Getting Started

  • Use Search if you know exact parameters or search terms (chemical, species, etc.)
  • Use Explore to see what data may be available in ECOTOX (including data plots)

Other Links

ECOTOX-related documentation and resources.

New Additions!

The latest updates to the ECOTOX Knowledgebase.

Search Tip

Example usage of ECOTOX Knowledgebase

ASCII Download

Download the entire database as an ASCII file via the button below.

Literature Search Dates

Targeted literature searches are conducted using chemical names, synonyms, and CASRNs in multiple search engines (e.g., Web of Science, Agricola, ToxNet, ProQuest, etc). Chemicals listed below had targeted searches corresponding to the date indicated in the second column. Each search is identified in the table by the requested chemical or chemical group, with some searches including multiple chemicals/CASRNs.

Citations from these searches will undergo data abstraction if the studies meet the inclusionary criteria for ECOTOX. Toxicity data results may take 6 months or longer to appear on-line. There may be more recent publications in ECOTOX for a chemical due to related chemical literature searches.


New Additions!

In addition to chemical data updates, ECOTOX has added new features based on user feedback:

  1. Several minor updates that improve the functionality in Search and Explore, including the ability the copy a citation in the display tables by clicking on the author name(s) in the Reference field, and more details provided about the number of references and records added or edited each quarter (found at: [ See update totals ]).
  2. DSSTox Substance Identifiers (DTXSIDs) continue to be updated each quarter. There are now over 12,500 chemicals for which DTXSID can be displayed and exported. In SEARCH, DTXSID can be added by clicking on the 'Customize Output Fields' button. Results tables in both SEARCH and EXPLORE include links from the DTXSID field directly to the EPA's [ Chemicals Dashboard ]. DTXSID is also provided in the ASCII Download Chemicals table.
  3. Duration can be used as a filter parameter in both SEARCH and EXPLORE to limit the results returned to a specific value or range for the Observed Duration, in days. The Observed Duration is the time at which an effect measurement was observed/measured and reported (for example, a 24-hour LC50). See the new Search Tip on how to apply this filter in SEARCH.

Did you know? There are multiple resources on how to use ECOTOX, including:
— The new ECOTOX Knowledgebase Virtual Training recording and slide deck (presented in May 2022) that are now available on the EPA's new New Approach Methods (NAMs) Training website. This training website includes resources for multiple tools. To find the most recent ECOTOX trainings, filter the Topic and Subtopic to 'Ecotoxicology' and sort by Year.
Help page which includes the ECOTOX User Guide, Learning the Basics, Data Field Definitions and Terms, and the Terms Appendix with the ECOTOX-specific controlled vocabulary.
Contact Us page where you can submit comments and questions about ECOTOX including technical questions about conducting queries and exporting data.

Search Tip

Using Duration Filter in SEARCH

Duration was recently added as a filter parameter that you can apply in both SEARCH and EXPLORE queries to limit the results returned to a specific value or range for the Observed Duration, in days. [The Observed Duration is the time at which an effect measurement was observed/measured and reported (for example, a 24-hour LC50).]

The following is an example how you can apply the Duration filter in SEARCH.

  1. From SEARCH, expand "All Test Conditions", Test Conditions sidebar menu, on the left-hand side under "Parameters".
  2. Scroll to the bottom of the expanded "All Test Conditions" section to find the options under "Specify Duration (Observed)".
  3. Search filters to specify duration
  4. Filter results to a specific duration returned by typing the requested duration in days, as a number, in the text box under "Insert specific duration (days)". For example, if you are only interested in 24-hour LC50s, type 1 under "Insert specific duration (days)", The value one day is set in the duration filter., and then also go to the "All Endpoints", Endpoints sidebar menu, section under "Parameters" to select "LC50" Endpoint LC 50 is selected..
  5. Then select the green "Update Search" button, Update Search button, on the bottom left-hand side to apply filters and view resulting records.
  6. If you are instead interested in a range for duration, enter the minimum, maximum, or both minimum and maximum under "Enter range for duration (days)".
  7. Duration range search filter.
  8. The results table will include the records that meet the parameters you selected and/or entered within Chemical, Species, Effects, Endpoints, Test Conditions, and Publication Options windows under "Parameters" in SEARCH.
  9. You can restore the default selections across all parameters by clicking on the "Reset All" button Reset All button, or within a single window by clicking on the "Reset" button in top right of a window Reset button.
  10. In the results table, the Obs. Dur. (Days) column will reflect the Duration filter you applied. To include additional data fields such as the Author Reported Observed Duration in the displayed and exported table, select "Customize Output Fields" Customize output fields button and select from the list of available fields.

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