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Study Details

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Information Source
Pereira, C., et al. 2007. "A Two-Generation Chronic Mixture Toxicity Study of Clophen A60 and Diethyl Phthalate on Histology of Adrenal Cortex and Thyroid of Rats." Acta Histochemica 109:29-36.
Age when Exposed*
age description below
Prenatal
includes Prenatal		 Infant includes Infant Child includes Child Adult Female includes Adult Female Adult Male includes Adult Male
Age when Assessed*
age description below
Prenatal
 Infant Child Adult Female includes Adult Female Adult Male includes Adult Male
Chemical Phthalates
Exposure Source Experimental
Exposure Medium Blood
Experimental
Exposure Route Placental Transfer
Ingestion
Species Rat
Study Description and Health Effects/Endpoints This two-generational study evaluated potential endocrine effects in rats that followed developmental exposure to polychlorinated biphenyls (PCBs) and diethyl phthalates (DEPs). The PCB mixture Clophen A60 was tested.

All parents and offspring of PCB, DEP, and PCB+DEP exposure groups had structural changes in the thyroid gland when compared to control groups, as measured by histology. Changes in thyroid were more pronounced in the male offspring PCB+DEP exposure group as compared to other exposure groups.

Female offspring of PCB-only exposure group and male offspring in all 3 exposure combinations had similar changes in the adrenal gland as compared to unexposed control groups.

The authors concluded that exposure to Clophen A60 and DEP together resulted in a synergistic effect in thyroid of male offspring and an antagonistic effect in the adrenal gland of female offspring. Effects of ClophenA60 and DEP exposure persisted through two generations.

Exposure Information and Comments/Notes Adult male and female rats were fed Clophen A60 (PCBs) or DEP, or PCBs and DEP together at 2.8 mg/kg body weight (bw)/day beginning 100 days before mating and continuing through gestation and weaning.

Offspring were fed with PCBs or DEP, or PCBs and DEP at 1.425 mg/kg bw/day beginning when offspring weighed 75-100 g and continued for 150 days (adulthood).

Editorial Comments none

 

Descriptions of Ages  
Prenatal: germ cell up to birth.
Infant: human: 0-1 year old; animal: newborn suckling (approximately 0-1 week old for rodents).
Child: human: 1-18 years old; animal: suckling, not weaned.
Adult: human: >18 years old; animal: weaned.

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