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Study Details
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Information Source
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Mahood, I.K., et al. 2006. "Cellular Origins of Testicular Dysgenesis in Rats Exposed In Utero to Di(n-butyl) Phthalate." International Journal of Andrology 29:148-154. |
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| Age when Exposed* age description below |
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| Age when Assessed* age description below |
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| Chemical | Phthalates | |||||
| Exposure Source | Experimental | |||||
| Exposure Medium | Blood Experimental | |||||
| Exposure Route | Gavage Placental Transfer | |||||
| Species | Rat | |||||
| Study Description and Health Effects/Endpoints |
This study characterized abnormalities in testes tissue in male offspring following maternal exposure to di(n-butyl) phthalate (DBP) during pregnancy. Testes were evaluated microscopically using immunohistochemistry to identify specific cell types. DBP-exposed testes had been shown to have abnormal clusters of large Leydig cells (LC), which are a specific type of cell found in testes, trapped in areas where seminiferous tubules were forming. These abnormal cells have been called intratubular Leydig cells (ITLC). This study demonstrated that ITLC were indeed a type of LC, and abnormalities in development in DBP-exposed offspring resulted in the abnormal location of these cells in tubules within the testes. |
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| Exposure Information and Comments/Notes |
Pregnant females were treated with 500 mg/kg/day of DBP via gavage from embryonic day 13.5-21.5. Offspring were evaluated at 25 days of age. “Only testes that were in a scrotal position and had normally developed epididymides were included in the present study to avoid possible confounding effects.” |
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| Editorial Comments | none |
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