Science Inventory

Next >>

Toxicological outcomes in vivo result from complex interactions among molecular, cellular and tissue-level damage responses which are difficult to recapitulate in vitro or extrapolate from data-based Machine Learning or molecular-level computer simulations. Mechani...

This is a lecture to the Colorado Produced Water Consortium to review methods that are used by EPA to evaluate chemicals and mixtures.

Hepatic steatosis (fatty liver disease) is a pathological condition that may alter xenobiotic metabolism, thereby increasing susceptibility to environmental toxicants. Here we used a metabolically competent human liver-derived cell line – HepaRG – to model steatosis f...

EPA is committed to making evidence-based decisions pertaining to the methodologies used in EPA analyses, guided by the best available science and input from the public and peer reviewers. Thus, as noted in previous EPA regulatory impact analyses, EPA is continuously reviewing de...

This sub-product provides an overview on our work with novel technologies to separate and destroy PFAS in residual waste streams (e.g., incinerator scrubber water, reverse osmosis retentate). This presentation focuses on a stepwise process where adsorbents first separate PFAS and...

Community decision making based on the sustainability of ecosystem services is an integrated process that involves multiple complex decisions and is greatly aided by an understanding of how those decisions are interrelated. The interrelatedness of decisions can be understood and ...

The purpose of this work is to provide data and information to refine existing guidance about how to flush per- and polyfluoroalkyl substances (PFAS) from firefighting systems, specifically hangar systems and Aircraft Rescue and Firefighting (ARFF) vehicles. It is relevant to the...

Radioactive fallout could have debilitating effects on drinking water and wastewater systems. At least some drinking water system operators have plans to mitigate the effects of a contaminated water source, but most, if not all, wastewater operators have no such plans.  Both...

Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based biomonitoring guidance values, but to locate these values, interested parties need to seek them out individually fro...

Evidence suggests that clothing can influence human exposure to semi-volatile organic compounds (SVOCs) through transdermal uptake and inhalation. Accordingly, a computational modeling framework (ABICAM) was expanded and applied to assess the dynamics of human exposure to gas-pha...

Legionella pneumophila (Lp) is an opportunistic drinking water pathogen that can cause infections through the inhalation of Lp-containing aerosols. Lp can occur in premise plumbing systems as these systems often have low disinfection residual, high surface area-to-volume ratios, ...

The threat of cascading and compounding disasters in low-income and underrepresented communities with hazardous and polluting sites makes urgent the need to build resilience. The Equitable Resilience Builder (ERB) is a new tool designed for situations where capacity and resources...

This presentation covers updates as of March 2024 regarding EPA methods for per- and polyfluoroalkyl substances (PFAS) as well as ongoing method development work within EPA Office of Research and Development (ORD). EPA Methods 1633 and 1621 were finalized on January 31, 2024. Fut...

These are slides to give an overview of applied NAMs for hazard, using the example workflow of performing an endocrine assessment using ToxCast data and models, followed by calculation of a bioactivity:exposure ratio. Then, examples of applied bioactivity:exposure ratios or point...

Phagocytosis is essential for proper innate immune defense across many organisms. When exposed to immunosuppressive environmental chemicals, phagocytosis may be inhibited, potentially increasing susceptibility to pathogens. To quantify the immunosuppressive potential of a chemica...

Controlled laboratory experiments are often performed on amphibians to establish causality between stressor presence and an adverse outcome. However, in the field, identification of lab-generated biomarkers from single stressors and the interactions of multiple impacts are diffic...

Presentation to the European Regulation & Innovation Forum (ERIF) Science Taskforce Meeting April 2024. The US Environmental Protection Agency works with program offices internally, other US federal Agencies, international partners, and diverse stakeholder groups to develop m...

Impoverished and under-served communities are often exposed to the worst environmental and climate hazards. Identifying these communities and building their resilience capacity to withstand such hazards is a vital justice aspect of environmental management. Building community res...

Non-perennial river segments — those that recurrently cease to flow or frequently dry — occur in all river networks and are globally more abundant than perennial (always flowing) segments. However, research and management have historically focused on perennial river s...

While SWMM has arguably played a pivotal role in pollution control in collection systems since its introduction, traditional applications using the model have been relatively static. They typically involve calibrating and validating SWMM models with data collected and curated for...

The development of science-based restoration goals that reflect the primary motivation of stakeholders is a key factor leading to large-scale, long-term restoration successes. The ability to predict the potential ecosystem service delivery from restoration can inform the setting ...

This research investigated the in-situ decay rates of four human wastewater-associated markers (Bacteroides HF183 (HF183), Lechnospiraceae Lachno3 (Lachno3), cross-assembling phage (crAssphage), pepper mild mottle virus (PMMoV) and three enteric viruses (human aden...

Partitioning of per- and polyfluoroalkyl substances (PFAS) to indoor materials, including clothing, may prolong the residence time of PFAS indoors and contribute to exposure. During the Indoor PFAS Assessment (IPA) Campaign, we measured concentrations of nine neutral PFAS in air ...

With increasing public awareness of PFAS, and their presence in biological and environmental media across the globe, comes a matching increase in the number of PFAS monitoring studies. As more matrices and sample cohorts are examined, there are more opportunities for matrix inter...

Background: Quality assurance (QA) and quality control (QC) practices are key tenets that facilitate study and data quality across all applications of untargeted metabolomics. These important practices will strengthen this field and accelerate its success. The Best Practices...