Science Inventory

Refine Your Search

Search Again

Search Within

Search Results

Search Criteria:

Records with

Person's Name = Kevin Crofton,
Person's Role = Any.

(Sorted by Fiscal Year)

Records 1 to 25 of 253

Next >>

2023

Harmonized Cross-Species Assessment of Endocrine and Metabolic Disruptors by Ecotox FACTORIAL Assay
(JOURNAL) [Published : Oct 06, 2020]

Environmental pollution is a threat to humans and wildlife species. Of particular concern are endocrine disrupting chemicals (EDCs). An important target of EDCs is nuclear receptors (NRs) that control endocrine and metabolic responses through transcriptional regulation. Owing in ...

2022

Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches
(JOURNAL) [Published : May 01, 2022]

Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development of more informative alternative methods to assess developmental (DNT) and ...

2021

Evaluating chemicals for thyroid disruption: opportunities and challenges with in vitro testing and adverse outcome pathway approaches
(JOURNAL) [Published : Sep 05, 2019]

Background: Extensive clinical and experimental research documents the potential for chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets. Perturbation of TH signaling can lead to abnormal brain development, cognitive impairments, and othe...

NAFTA Developmental Neurotoxicity Guidance Document: Case Study – Chemical X
(PRESENTATION) [Presented : Apr 26, 2021]

A series of lectures on developmental neurotoxicology guideline (DNT) studes were presented to the European Food Safety Association (EFSA) by the three authors on this presentation. This seminar expanded on these previous educational seminars by exploring a Case Study of a typica...

2020

Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library
(JOURNAL) [Published : Sep 30, 2019]

Interference with receptors of the endocrine system by xenobiotic chemicals is of great importance for protecting the health of humans and wildlife. Thyroid hormone receptors (TR) are critical endocrine receptors which regulate a multitude of processes in adult and developing org...

2019

International regulatory and scientific effort for improved developmental neurotoxicity testing
(JOURNAL) [Published : Nov 23, 2018]

The Organisation for Economic Co-Operation and Development (OECD) coordinates international efforts to enhance developmental neurotoxicity (DNT) testing. In most regulatory sectors, including the ones dealing with pesticides and industrial chemicals registration, historical use o...

High-throughput literature mining to support read-across predictions of toxicity
(PAPER IN NON-EPA PROCEEDINGS) [Published : Feb 01, 2017]

Building scientific confidence in the development and evaluation of read-across remains an ongoing challenge. Approaches include establishing systematic frameworks to identify sources of uncertainty and ways to address them. One source of uncertainty is related to characterizing ...

2018

Development of a Human 3D Prostate Microtissue Assay for Anti-androgen Screening
(PRESENTATION) [Presented : Mar 15, 2018]

Altered androgen hormone biosynthesis and metabolism can modulate androgen levels, contributing to endocrine disruption that may result in impaired reproductive and sexual development. Steroid 5α-reductase isozymes are expressed in key peripheral tissues and catalyze the conversi...

Update on NCCT Transcriptomic and Metabolic Retrofit Projects
(PRESENTATION) [Presented : Oct 10, 2017]

Presentation to Endocrine Policy Forum Oct 2017

Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing
(JOURNAL) [Published : Nov 21, 2016]

ABSTRACTWorldwide concern about the impacts of endocrine disrupting compounds on both human and environmental health has led to implementation of multiple screening and testing programs. In most cases these programs have focused on impacts to the estrogen, androgen and thyroid h...

Screening the 10K Tox21 chemical library for thyroid hormone receptor modulators
(PRESENTATION) [Presented : Mar 15, 2018]

Few ligands for the thyroid hormone receptor (TR) have been identified outside of endogenous ligands and pharmaceuticals, which suggests that TR is a very selective nuclear receptor (NR). However, large and diverse chemical libraries, particularly of environmental chemicals, have...

FutureTox III: Bridges for Translation
(JOURNAL) [Published : Jan 01, 2017]

The present document describes key discussion points and outcomes of a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) Workshop, entitled FutureTox III1,2 that was held in Crystal City, Virginia, November 19-20, 2015. The workshop built on the many lessons l...

Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays
(JOURNAL) [Published : May 03, 2017]

Pyrethroid insecticides exert their insecticidal and toxicological effects primarily by disrupting voltage-gated sodium channel (VGSC) function, resulting in altered neuronal excitability. Numerous studies of individual pyrethroids have characterized effects on mammalian VGSC fun...

Text-mining strategies to support computational research in chemical toxicity (ACS 2017 Spring meeting)
(PRESENTATION) [Presented : Apr 06, 2017]

With 26 million citations, PubMed is one of the largest sources of information about the activity of chemicals in biological systems. Because this information is expressed in natural language and not stored as data, using the biomedical literature directly in computational resear...

Supporting read-across predictions of chemical toxicity using high-throughput text-mining (ACS 2017 Spring meeting )
(PRESENTATION) [Presented : Apr 06, 2017]

Read-across is a technique used to fill data gaps within chemical safety assessments. It is based on the premise that chemicals with similar structures are likely to have similar biological activities. Known information on the property of a chemical (source) is used to make a pre...

Using high-throughput literature mining to support read-across predictions of skin sensitization (WC)
(PRESENTATION) [Presented : Aug 24, 2017]

Read-across predictions require high quality measured data for source analogues. These data are typically retrieved from structured databases, but biomedical literature data are often untapped because current literature mining approaches are resource intensive. Our high-throughpu...

Optimization Of A High-Throughput Transcriptomic (HTTr) Bioactivity Screen In MCF7 Cells Using Targeted RNA-Seq (SOT)
(PRESENTATION) [Presented : Mar 16, 2017]

Recent advances in targeted RNA-Seq technology allow researchers to efficiently and cost-effectively obtain whole transcriptome profiles using picograms of mRNA from human cell lysates. Low mRNA input requirements and sample multiplexing capabilities has made time- and concentrat...

Screening the Tox21 10K library for thyroid stimulating hormone receptor agonist and antagonist activity (SOT annual meeting)
(PRESENTATION) [Presented : Mar 16, 2017]

Thyroid-stimulating hormone (TSH) regulates thyroid hormone (TH) production via binding to its receptor (TSHR). The roles of TSHR in human pathologies including hyper/hypothyroidism, Grave’s disease, and thyroid cancer are known, but it is currently unknown whether TSHR is an imp...

Using high-throughput literature mining to support read-across predictions of toxicity (SOT)
(PRESENTATION) [Presented : Mar 16, 2017]

Stakeholder engagement and feedback efforts to increase use of the iCSS ToxCast Dashboard (SETAC)
(PRESENTATION) [Presented : Nov 02, 2015]

In the era of ‘Big Data’ research, many government agencies are engaged in generating and making public large amounts of data that underly both research and regulatory decisions. Public access increases the ‘democratization’ of science by enhancing transparency and access. Howev...

Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments
(JOURNAL) [Published : Jun 01, 2015]

Regulatory agencies often utilize results from peer reviewed publications for hazard assessments.A problem in doing so is the lack of well-accepted tools to objectively, efficiently and systematically assess the quality of published toxicological studies. Herein, we evaluated the...

Expanding the test set: Chemicals with potential to disrupt mammalian brain development
(JOURNAL) [Published : Nov 01, 2015]

High-throughput test methods including molecular, cellular, and alternative species-based assays that examine critical events of normal brain development are being developed for detection of developmental neurotoxcants. As new assays are developed, a "training set' of chemicals i...

Environmentally relevant mixing ratios in cumulative assessments: a study on the correlation of blood and brain concentrations of a mixture of pyrethroid insecticides to neurotoxicity in the rat
(JOURNAL) [Published : Jun 01, 2016]

Human exposure to multiple pyrethroid insecticides may occur because of their broad use on crops and for residential pest control. To address the potential health risk from co-exposure to pyrethroids, it is important to understand their disposition and toxicity in target organs ...

A Network of AOPs for reduced thyroid hormone synthesis derived from inhibition of Thyroperoxidase - A common Molecular Initiating Event Leading to Species-Specific Indices of Adversity.
(EXTRAMURAL DOCUMENT) [Published : Sep 01, 2016]

This collection of 3 AOPs describe varying outcomes of adversity dependent upon species in response to inhibition of thyroperoxidase (TPO) during development. Chemical inhibition of TPO, the molecular-initiating event (MIE), results in decreased thyroid hormone (TH) synthesis, a...

2017

Computational Toxicology in EPA (CS SOT MEETING)
(PRESENTATION) [Presented : Nov 18, 2016]

Presentation at Central States SOT meeting in Iowa City, IA.