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Clean air and water, ample food, renewable fuels, productive fisheries, diverse ecosystems, resilient coasts and watersheds: these are some of the benefits that depend on sustainable nitrogen use and management. Thus, in our vision of the future, uses of reactive nitrogen are suf...

Nitrogen is a critical component of the economy, food security, and planetary health. Many of the world&rsquo;s sustainability targets hinge on global nitrogen solutions, which, in turn, contribute lasting benefits for: (i) world hunger; (ii) soil, air and water pollution; (iii) ...

Computational approaches were developed to identify factors that regulate Nrf2 in a large gene expression compendium of microarray profiles including &gt;2000 comparisons which queried the effects of chemicals, genes, diets, and infectious agents on gene expression in the mouse l...

A number of putative AOPs for several distinct MIEs of thyroid disruption have been formulated for amphibian metamorphosis and fish swim bladder inflation. These have been entered into the AOP knowledgebase on the OECD WIKI.

Ecological risk assessments are often limited in their ability to consider metabolic transformations for fish species due to a lack of data. When these types of evaluations are attempted they are often based on parent chemical only, or by assuming similarity to available mammali...

Engineered nanomaterials (ENM) are a growing aspect of the global economy, and their safe and sustainable development, use and eventual disposal requires the capability to forecast and avoid potential problems. This review is concerned with the releases of ENM into the environmen...

A challenge for both human health and ecological toxicologists is the transparent application of mechanistic (e.g., molecular, biochemical, histological) data to risk assessments. The adverse outcome pathway (AOP) is a conceptual framework designed to meet this need. Specifically...

A tremendous amount of data on environmental stressors has been accumulated in exposure science, epidemiology, and toxicology, yet most of these data reside in different silos. The Adverse Outcome Pathway (AOP) framework was developed as an organizing principle for toxicological ...

This seminar for Oregon State University&rsquo;s Water Resources Graduate Program will describe the use of a spatially-distributed ecohydrological model, VELMA, for quantifying how alternative land use and climate scenarios affect tradeoffs among important ecosystem services. Sp...

Trenbolone acetate is widely used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17β‐trenbolone, have been detected at low nanograms per liter concentrations in surface waters associated with animal feedlo...

Chemicals in the environment can prevent proper reproduction in fish. However, it was unknown whether models developed using data collected from the commonly studied fathead minnow could accurately predict adverse effects to other fish species. Results of our study suggest that t...

In vitro estrogen receptor assays are valuable screening tools for identifying environmental samples and chemicals that display estrogenic activity. However, in vitro potency cannot necessarily be extrapolated to estimates of in vivo potency because in vitro assays are currently...

The EPA&rsquo;s vision for the Endocrine Disruptor Screening Program (EDSP) in the 21st Century (EDSP21) includes utilization of high-throughput screening (HTS) assays coupled with computational modeling to prioritize chemicals with the goal of eventually replacing current Tier 1...

Lipid levels are regulated in mammals by sterol regulatory element-binding proteins (SREBPs). To identify chemicals that might cause steatosis through SREBP, a mouse gene expression biomarker was characterized that can predict modulation of SREBP family members. Using microarray ...

We propose the use of gene expression profiling to complement the chemical characterization currently based on HTS assay data and present a case study relevant to the Endocrine Disruptor Screening Program. We have developed computational methods to identify estrogen receptor &alp...

A generic Transcriptomics Reporting Framework (TRF) is presented that lists parameters to take into consideration in designing and reporting &lsquo;omics studies in a regulatory context. The TRF takes the example of microarray studies for transcriptome profiling from data generat...

The Adverse Outcome Pathway (AOP) framework represents an ideal tool for integrating diverse data relating chemical exposures to adverse outcomes. Glucocorticoid signaling is tightly controlled and numerous adverse health outcomes have been associated with either elevation or sup...

Ecosystem-based management involves the integration of ecosystem services and their human beneficiaries into decision making. This can occur at multiple scales; addressing global issues such as climate change down to local problems such as flood protection and maintaining water q...

We present an integrated assessment model to predict potential unintended consequences of urban development on the sustainability of seagrasses and preservation of ecosystem services, such as catchable fish, in Tampa Bay. Ecosystem services are those ecological functions and pro...

From determining what to have for lunch to deciding where to invest our resources, we, as individuals and societies, are constantly involved in multi-criteria assessment. Using sustainability assessment as a case study, in this talk I will demonstrate the ubiquity of multi-crite...

Product Description: CRISPR/Cas9 is a system that can be used to disrupt a gene of interest in any animal. It allows us to study each gene&rsquo;s role by observing changes in the animal when the gene isn&rsquo;t functional. We worked out a method to use this technology in the f...

This product is a regional conference abstract and award application. The abstract primarily serves as the application for the NCSOT PARC Award and secondarily as a poster abstract for the fall meeting of NCSOT at NIEHS.

Recordings of neural network activity in vitro are increasingly being used to assess the development of neural network activity and the effects of drugs, chemicals and disease states on neural network function. The high-content nature of the data derived from such recordings can ...

The fish short term reproduction assay (FSTRA) is a key component of the USEPA endocrine disruptor screening program (EDSP). The FSTRA considers several mechanistic and apical responses in fathead minnows (Pimephales promelas) to determine whether an unknown chemical is likely t...

The fish short term reproduction assay (FSTRA) is a key component of the USEPA endocrine disruptor screening program (EDSP). The FSTRA considers several mechanistic and apical responses in fathead minnows (Pimephales promelas) to determine whether an unknown chemical is likely to...