You are here:
INDUCTION OF NITRIC OXIDE SYNTHASE AND ASSOCIATED TOXICITY IN LIVERS OF HARDHEAD CATFISH, ARIUS FELIS, FROM CONTROL AND EPIZOOTIC SITES
Citation:
Schoor, W P. INDUCTION OF NITRIC OXIDE SYNTHASE AND ASSOCIATED TOXICITY IN LIVERS OF HARDHEAD CATFISH, ARIUS FELIS, FROM CONTROL AND EPIZOOTIC SITES. U.S. Environmental Protection Agency, Washington, DC, EPA/540/R-12/002, 1997.
Impact/Purpose:
Report
Description:
Earlier work with a live channel catfish (Ictalurus punctatus) pathogen, Edwardsiella ictaluri, demonstrated the induction of nitric oxide synthase (NOS) in the head kidney, paralleling enteric septicemia (Hawke et al. 1981; Schoor and Plumb 1994). However, another study exposing hardhead catfish (Arius felis) to microcystine-LR failed to show the induction of NOS (Schoor et al. In prep.). Similar studies in mammalian systems have shown the involvement of the cytokines in the induction of NOS by a mechanism which may possibly have been bypassed by the pure toxin. In order to pursue these studies, the State of Florida Department of Natural Resources Laboratory in St. Petersburg, Florida, was contacted with a request for fish livers from an epizootic. Dr. Jan Landsberg answered the request in November of 1995.