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VALIDATION OF LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHODS: INTERLABORATORY STUDIES
Citation:
Jones-Lepp, T., L. Betowski, AND V. Lopez-Avila. VALIDATION OF LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHODS: INTERLABORATORY STUDIES. Trends in Analytical Chemistry 13(8):333-338, (1994).
Description:
Developments over the last 15 years led to widespread acceptance and commercialization of two liquid chromatography-mass spectrometry (LC-MS) interfaces: thermospray (TSP) and particle beam (PB). Very few LC-MS methods were developed and formally adopted, however, by the U.S. Environmental Protection Agency (EPA). This article addresses the difficulties encountered with current LC-MS instrumentation in validating the methods and discusses somr of the results of three interlabortory EPA studies, including a thermospray-LC-MS (TSP-LC-MS) study for chlorinated herbicides, a TSL-LC-MS study for carbamate pesticides, and a particle beam-LC-MS (PB-LC-MS) study for benzidines. Difference in features among the various LC-MS interfaces made it impractical to impose strict guidelines to the participants in conducting these analyses. Consequently, difficulties were encountered in analyzing the data; nonetheless, interesing and useful data as outlined were obtained.