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QUANTITATIVE TOXICOLOGIC PATHOLOGY-METHODS AND INTERPRETATION' SESSION AT THE JOINT MEETING OF SOCIETY OF TOXICOLOGIC PATHOLOGISTS AND THE INTERNATIONAL FEDERATION OF SOCIETIES OF TOXICOLOGIC PATHOLOGISTS
Citation:
Wolf, D C. QUANTITATIVE TOXICOLOGIC PATHOLOGY-METHODS AND INTERPRETATION' SESSION AT THE JOINT MEETING OF SOCIETY OF TOXICOLOGIC PATHOLOGISTS AND THE INTERNATIONAL FEDERATION OF SOCIETIES OF TOXICOLOGIC PATHOLOGISTS. Journal of Toxicologic Pathology. The Japanese Society of Toxicologic Pathology, TOKYO, Japan, 14(4):319-320, (2001).
Impact/Purpose:
To present findings on the value of quantitation in analysis of tissue response to xenobiotics and the need for and the use of quantitative histologic and molecular data for risk assessment
Description:
Report of the 'Quantitative Toxicologic Pathology - Methods and Interpretation' session at the Joint meeting of Society of Toxicologic Pathologists and the International Federation of Societies of Toxicologic Pathologists, Orlando, Florida, USA, June 24-28, 2001. Douglas C. Wolf, D.V.M., Ph.D., Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, ORD, U. S. EPA.
At the recent joint meeting of the Society of Toxicologic Pathologists and the International Federation of Societies of Toxicologic Pathologists a plenary session was presented entitled "Quantitative Toxicologic Pathology - Methods and Interpretation". This session was designed to address the value of quantitation in analysis of tissue response to xenobiotics. Current risk assessment guidelines, dose-response modeling, physiologically based pharmacokinetic models, and cancer growth models all require specific quantitative data for accurate model development. This session of the meeting examined the issue of quantitative versus qualitative analysis of non-neoplastic lesion reporting. Methods, rationale, and interpretation of data on quantitation of neoplastic processes were presented. Methods and rationale of quantitation of molecular events was addressed including the concept of gene dose-response. Finally, a discussion of the need for and the use of quantitative histologic and molecular data for risk assessment and development of a biologically based model was presented.