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MICROWAVE-ASSISTED PREPARATION OF CYCLIC UREAS FROM DIAMINES
Citation:
Varma*, R S. AND K. J. Kim**. MICROWAVE-ASSISTED PREPARATION OF CYCLIC UREAS FROM DIAMINES. Presented at American Chemical Society, Philadelphia, PA, August 22 - 26, 2004.
Impact/Purpose:
To inform the public
Description:
Rajender S. Varma* and Yong-Jin Kim
Cyclic ureas are useful intermediates for a variety of pharmaceuticals and pesticides. One of the attractive approaches for the synthesis of cyclic ureas uses condensation of diamines with urea as a carbonyl source under dynamic evacuation. A direct synthesis of cyclic urea is presented that proceeds expeditiously in the presence of ZnO. The reaction is accelerated upon exposure to microwave irradiation resulting in a shortened reaction time and eliminating the formation of side products when compared to methods involving conventional heating. Various reaction parameters influencing this condensation reaction will be presented including the extension of this work to related cyclic urethanes.