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RESIDENTIAL POST-APPLICATION EXPOSURE MONITORING
Citation:
Lewis, R G. RESIDENTIAL POST-APPLICATION EXPOSURE MONITORING. Chapter 3, J. P. Worgan and C. A. Franklin (ed.), Occupational and Incidental Residential Exposure Assessment. John Wiley & Sons, Ltd., Chichester, Uk, , 71-128, (2004).
Impact/Purpose:
The goal of this task is to contribute to a better understanding of human exposure to pesticides, especially for small children by developing methods to characterize sources and pathways in and around the residential environment. We will support the science behind FQPA and assist the Office of Pesticide Programs (OPP) in the development of guidelines for the assessment of residential exposure to pesticides. Specific research objectives include: (i) to evaluate and develop methods for measuring pesticides in air using passive/diffusive samplers. Assess and refine devices for the collection of surface transferable pesticide residues and to establish transfer efficiencies; (ii) to develop and apply analytical methods for new and emerging pesticides using both gas and liquid chromatographic methods in support of the National Exposure Research Laboratory's (NERL) Human Exposure Measurement Project; and, (iii) to conduct pilot studies investigating chiral chromatographic methods.
Description:
Methods of measurement of pesticide exposures can be separated into two categories: direct and indirect (Briston et al., 1984, Nigg et al. 1990). Direct methods measure a pesticide residue in environmental media or on the skin surface before it has entered the body in order to estimate the potential dose. Indirect methods estimate the minimum absorbed dose by measuring residues in excreta, body fluids, or tissue after exposure has occurred. Examples of direct methods are those that determine residues in the air, water, on surfaces, and in food. Indirect methods may involve determination of the levels of specific pesticides, their metabolites, or biological indicators (biomarkers), such as a protein- or DNA-adducts, in blood, urine, feces, sputum, sebum, cerumen, or adipose tissue. This chapter covers direct measurement methods only.
This product is a book chapter published December 1, 2004. CITATION: Lewis, R.G. Residential Post-Application Exposure Monitoring. Chapter 3, J.P. Worgan and C.A. Franklin (ed.), Occupational and Incidental Residential Exposure Assessment. John Wiley & Sons, Ltd., Chichester, UK, 71-128, (2004).