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EFFICIENT CHEMICAL SYNTHESIS USING MICROWAVES
Citation:
Varma*, R S. AND Ju**,Y. EFFICIENT CHEMICAL SYNTHESIS USING MICROWAVES. Microwave Science and its Application to Related Fields, Takamatsu, JAPAN, March 30 - July 30, 2004.
Impact/Purpose:
To inform the public.
Description:
Synthetic organic transformations performed under non-traditional conditions are becoming popular primarily to circumvent the growing environmental concerns. A solvent-free approach that involves microwave (MW) exposure of neat reactants catalyzed by the surfaces of less-expensive and recyclable mineral supports such as alumina, silica, clay, or 'doped' surfaces will be described which is applicable to a wide range of cleavage, condensation, cyclization, rearrangement, oxidation and reduction reactions including rapid one-pot assembly of heterocyclic compounds from in situ generated reactive intermediates. The strategy is adaptable for multi-component reactions such as Ugi and Biginelli reactions for rapid assembly of a library of compounds. The solvent-free preparation of room temperature ionic liquids and an environmental-friendlier synthesis of tertiary amines in aqueous medium via direct N-alkylation of amines by alkyl halides under MW irradiation wil be described. The one pot generation of propargyl amines via in situ formation of imines followed by Grignard type addition of alkynes under MW influence using only Cu (1) will be highlighted that has potential for enantioselective construction of new chiral centers.