You are here:
GENE EXPRESSION PROFILING TO IDENTIFY BIOMARKERS OF REPRODUCTIVE TOXICITY
Citation:
Dix, D J. GENE EXPRESSION PROFILING TO IDENTIFY BIOMARKERS OF REPRODUCTIVE TOXICITY. Presented at Society of Toxicology, New Orleans, LA, March 6-10, 2005.
Description:
SOT 2005 SESSION ABSTRACT
GENE EXPRESSION PROFILING TO IDENTIFY BIOMARKERS OF REPRODUCTIVE TOXICITY
David J. Dix. National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711.
Testicular gene expression has been analyzed in rodents exposed to a variety of chemicals to identify biomarkers predictive or indicative of toxicity and impaired reproductive health. Using DNA microarrays we identified numerous biomarkers of reproductive toxicity in mouse and rat testes. In some cases these biomarkers were unique to the chemical or class of chemical exposures, while other biomarkers were associated with impaired reproductive function irrespective of exposure specifics. In order to extrapolate this animal research to considerations of human reproductive health, profiles of gene expression in human testis, sperm and steroidogenic cells were compared to profiles of rodent gene expression. Similarities between testis, sperm and cellular profiles; and rodent and human profiles, indicate the potential for using this type of toxicogenomic data for understanding chemical risks to human reproductive health. This abstract does not necessarily reflect EPA policy.