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NANOMETER SIZE DIESEL EXHAUST PARTICLES ARE SELECTIVELY TOXIC TO DOPAMINERGIC NEURONS: THE ROLE OF MICROGLIA, PHAGOCYTOSIS, AND NADPH OXIDASE.
Citation:
Block, M. L., X. Wu, Z. Pei, G. Li, T. Wang, L. Qin, B. Wilson, J. Yang, J. S. Hong, AND B Veronesi. NANOMETER SIZE DIESEL EXHAUST PARTICLES ARE SELECTIVELY TOXIC TO DOPAMINERGIC NEURONS: THE ROLE OF MICROGLIA, PHAGOCYTOSIS, AND NADPH OXIDASE. FASEB JOURNAL.
Impact/Purpose:
To evaluate the neurotoxic response of cultured brain cells to diesel exhaust particles
Description:
This manuscript describes the neurotoxic response of cultured brain cells to diesel exhaust particles (DEP). DEP produces an early production of free radicals (i.e., oxidative stress) in one CNS cell type (the microglial) and the subsequent degeneration of specific neuronal populations (dopaminergic neurons). Such experimental data should alert us to the potential neurotoxic consequences of diesel entry into the brain.