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OXIDATIVE DAMAGE-RELATED GENES AKR1C3 AND OGG1 MODULATE RISKS FOR LUNG CANCER DUE TO EXPOSURE TO PAH-RICH COAL COMBUSTION EMISSIONS
Citation:
Lan, Q., J L. Mumford, M. Shen, D M. Demarini, M. R. Bonner, X. He, M. Yeager, R. Welch, S. Chanock, L. Tian, R S. Chapman, T. Zheng, P. Keohavong, AND N. Caporaso. OXIDATIVE DAMAGE-RELATED GENES AKR1C3 AND OGG1 MODULATE RISKS FOR LUNG CANCER DUE TO EXPOSURE TO PAH-RICH COAL COMBUSTION EMISSIONS. CARCINOGENESIS 25(11):2177-2181, (2004).
Impact/Purpose:
To determine whether polymorphisms in oxidative stress genes influence lung cancer risk
Description:
We studied polymorphisms in genes that generate, prevent, or repair oxidative damage and lung cancer risk among 118 cases and 113 controls in Xuan Wei China, where extremely high lung cancer rates are caused by indoor exposure to smoky coal. SOD2-Vak16Ala and NQO1-Pro 187Ser were not associated with risk. However, the AKR1 C3 Gin/Gin allele and combined OGG1 Cys/Cys and Ser/Cys alleles in highly exposed nonsmoking women were associated with increased risk (OR = 15.23; 95% Confidence Interval (Cl) = 2.77-83.68 and OR = 6.40; 95% CI = 1.38-29.68, respectively). This provides the first evidence that polymorphisms in oxidative stress genes influence lung cancer risk among women in this population