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STRUCTURE-ACTIVITY COMPARISON OF ORGANOTIN SPECIES: DIBUTYLTIN IS A DEVELOPMENTAL NEUROTOXICANT IN VITRO AND IN VIVO.
Citation:
Jenkins, S., K. Ehman, AND S Barone. STRUCTURE-ACTIVITY COMPARISON OF ORGANOTIN SPECIES: DIBUTYLTIN IS A DEVELOPMENTAL NEUROTOXICANT IN VITRO AND IN VIVO. DEVELOPMENTAL BRAIN RESEARCH 151:1-12, (2004).
Impact/Purpose:
To compare the toxicity of organotin species present in drinking water using structure-activity comparisons
Description:
This manuscript compares the toxicity of a number of organotin species present in drinking water using a set of in vitro assays that model neuronal differentiation, and viability and apoptosis. Dibutyltin (DBT), dimethyltin (DMT), monomethyltin (MMT), and the positive control trimethyltin (TMT) were examined for potency in these assays. Surprisingly, the most potent organotin species that had effects in this mini developmental battery was DBT. The effects of DBT were observed in the low micromolar range in assays of all three processes. These in vitro results were extended by evaluating the effects of developmental exposure to DBT in vivo. Consistent with the in vitro findings, in vivo DBT exposure increased the occurrence of apoptosis in multiple brain regions. The focus was limited to measures of apoptosis and were observed at a number of brain regions. This paper suggest that further consideration of dibutyltin neurotoxicity is warranted.