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TOXICOKINETICS OF BDE 47 IN FEMALE MICE: EFFECTS OF DOSE, ROUTE OF EXPOSURE, AND MDR1 TRANSPORTER
Citation:
Staskal, D., J J. Diliberto, M J. DeVito, AND L S. Birnbaum. TOXICOKINETICS OF BDE 47 IN FEMALE MICE: EFFECTS OF DOSE, ROUTE OF EXPOSURE, AND MDR1 TRANSPORTER. Presented at BRF 2004, Toronto, Canada, June 6-9, 2004.
Description:
Introduction
2,2',4,4'-Tetrabromodiphenyl ether (BDE 47) is a polybrominated diphenyl ether (PBDE) congener used in a class of brominated flame retardants (BFRs) commonly used in a variety of highly flammable consumer goods. Concern for the effects of PBDEs has increased significantly in recent years as their presence has been detected in environmental samples and in human tissues at steadily increasing concentrations. Despite its small contribution to the PBDE global production and usage, BDE 47 is the major congener found in environmental samples and human tissue. Limited toxicology studies suggest that BDE 47 is a developmental neurotoxicant and an endocrine disruptor1; however, several data gaps exist and must be investigated in order to evaluate the human health risk of BDE 47.
This study investigates the basic toxicokinetic properties of BDE 47 in female C57BL/6J mice. Orn and Wehler2 have previously reported limited toxicokinetic properties of BDE 47 in male C57 mice following a single oral dose (30 umol/kg): here we report the effects of dose and route of exposure on the absorption, distribution, and excretion following a single, acute dose of 14C-labeled BDE 47. Data from these basic ADME studies will be applied to studies investigating the toxicokinetics of BDE 47 in a developmental model as well as in the development of a physiologically-based pharmacokinetic (PBPK) model.