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PRIORITIZATION OF NTP REPRODUCTIVE TOXICANTS FOR FIELD STUDIES
Citation:
Moorman, W. J., H. W. Ahlers, R. E. Chapin, G. P. Daston, P. Foster, R J. Kavlock, J. S. Morawetz, T. M. Schnorr, AND S. M. Schrader. PRIORITIZATION OF NTP REPRODUCTIVE TOXICANTS FOR FIELD STUDIES. REPRODUCTIVE TOXICOLOGY 14(4):293-301, (2000).
Description:
Population studies evaluate human reproductive impairment are time consuming,
expensive, logistically difficult and with limited resources must be prioritized to
effectivelyprevent the adverse health effects in humans. Interactions among
health scientists, unions,and industry can serve to identify populations exposed
to potential hazard and develop strategies to evaluate and apply appropriate
controls. This report describes a systematic method for prioritizing chemicals
that may need human reproductive healthfieldstudies.Rodentsreproductive
toxicants identified from the National Toxicology Program (NTP)Reproductive
Assessment by Continuous Breeding (RACB) protocol were prioritized on the
basis of potency of toxic effect and population at risk. This model for prioritization
links NTP finds with data from the National Occupation Exposure Survey (NOES)
and the Hazardous Substance Data Base (HSDB) or the High Production
Volume Chemical Database (HPVC) to prioritized chemicals for their potential
impact on worker populations. The chemicals with the highest priority for field
study were dibutyl phthalate, boric acid, tricresyl phosphate, and N,
N-dimethylformamide.