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A CONCEPTUAL MODEL FOR EVALUATING RELATIVE POTENCY DATA FOR USE IN ECOLOGICAL RISK ASSESSMENTS
Citation:
Cook, P. M. AND T. R. Henry. A CONCEPTUAL MODEL FOR EVALUATING RELATIVE POTENCY DATA FOR USE IN ECOLOGICAL RISK ASSESSMENTS. DIOXIN 2003: 23rd International Symposium of Halogenated Organic Pollutants and Persistent Organic Pollutants, Boston, MA, August 24-29, 2003.
Description:
For chemicals with a common mechanism of toxicity, relative potency factors (RPFs) allow dose and exposure measures to be normalized to an equivalent toxicity amount of a model chemical... In ecological risk assessments the large number of possible target species, variety of exposure scenarios, and differences in toxicity effects, both in laboratory studies and environmental settings, create a continuing need for sorting and selecting relative potency (ReP) data to obtain optimum TEF and/or RPF values for maximizing accuracy of site-specific toxicity equivalence concentration (TEC) calculations... In the 1997 WHO process, a tiered approach was followed in deriving the TEFs for fish and birds from the ReP data available... This developing conceptual model may also be useful for future revisions and additions to the WHO TEFs, as well as a framework for research planning and design.