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EFFECTS OF ETHINYL ESTRADIOL ON GONDAL DEVELOPMENT AND PATHOLOGY IN CUNNER, TAUTOGOLABRUS ADSPERSUS
Citation:
Zaroogian, G, D B. Horowitz, R GutjahrGobell, AND L J. Mills. EFFECTS OF ETHINYL ESTRADIOL ON GONDAL DEVELOPMENT AND PATHOLOGY IN CUNNER, TAUTOGOLABRUS ADSPERSUS. Presented at Society of Environmental Toxicology and Chemistry Annual Meeting, Baltimore, MD, November 11-15, 2001.
Description:
The intent of this study was to determine histopathologically the effect of ethinyl estradiol (EE2) on gonadal development, liver and kidney condition in reproductively active cunner, Tautogolabrus adspersus. Reproductively active cunner were treated by implanting EE2 in a slow release matrix (coconut oil, ethocel) subcutaneously near the dorsal fin. Treatments included a control, 0.05, 0.5 and 2.5 mg/kg EE2. Cunner were sampled 2 weeks later and observed histopathologically. A dose dependent relationship occurred in male gonads, where thickening of the connective tissue surrounding the seminal vesicles and regression of spermatogenesis increased with dose. A significant decline in ovarian development occurred in cunner treated with 2.5 mg/kg EE2. Both males and females in the 2.5 mg/kg treatment accumulated a hyaline material in their livers and in the tubules and glomeruli of their kidneys. Multiple glomeruli and inflammation in the kidneys were also observed in these fish. Histopathological changes relating to excessive accumulation of hyaline material, probably vitellogenin, were seen in hepatocytes, testicular tissues and renal glomeruli.