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SYNTHESIS OF HIGHLY FLUORINATED CHLOROFORMATES AND THEIR USE AS DERIVATIZING AGENTS FOR HYDROPHILIC COMPOUNDS AND DRINKING WATER DISINFECTION BY-PRODUCTS
Citation:
Vincenti, M., N. Ghiglione, M. C. Valsania, P. Davit, AND S D. Richardson. SYNTHESIS OF HIGHLY FLUORINATED CHLOROFORMATES AND THEIR USE AS DERIVATIZING AGENTS FOR HYDROPHILIC COMPOUNDS AND DRINKING WATER DISINFECTION BY-PRODUCTS. HELVETICA CHIMICA ACTA 87(2):370-375, (2004).
Impact/Purpose:
(1) Use toxicity-based approach to identify DBPs that show the greatest toxic response. (2) Comprehensively identify DBPs formed by different disinfectant regimes for the 'Four Lab Study'. (3) Determine the mechanisms of formation for potentially hazardous bromonitromethane DBPs.
Description:
A rapid, safe and efficient procedure was developed to synthesize perfluorinated chloroformates in the small scale generally required to perform analytical derivatizations. This new family of derivatizing agents allows straightforward derivatization of highly polar compounds, containing multiple hydroxylic, carboxylic and aminic substituents, directly in the aqueous phase, making them compatible with GC and GC-MS analysis. A goal of this work was to develop a derivatization procedure that would enable the detection and identification of highly polar disinfection byproducts in drinking water.