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PHARMACOKINETIC MODELING FOR PERFLUORINATED CHEMICALS USED IN HOUSEHOLD CONSUMER PRODUCTS
Citation:
Clark, L. H. AND H A. Barton. PHARMACOKINETIC MODELING FOR PERFLUORINATED CHEMICALS USED IN HOUSEHOLD CONSUMER PRODUCTS. Presented at SIAM Conference on the Life Sciences, Portland, OR, July 11-16, 2004.
Description:
PHARMACOKINETIC MODELING FOR PERFLUORONATED CHEMICALS USED IN HOUSEHOLD CONSUMER PRODUCTS
Leona H. Clark and Hugh A. Barton
US Environmental Protection Agency, ORD, NHEERL, ETD, Research Triangle Park, NC
The physiologically-based pharmacokinetic model to be presented describes the absorption, distribution, metabolism, and elimination of perfluorinated chemicals used in a variety of consumer products as oil, water, and grease repellants. The model is used to evaluate the fate of the chemicals in the body following oral exposure and provides a framework for dose-response analyses needed to help assess the risk the chemicals have on human health and the environment. (Abstract does not reflect EPA policy.)