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DSSTOX: NEW ON-LINE RESOURCE FOR PUBLISHING AND INTEGRATING STANDARDIZED STRUCTURE-INCLUSIVE TOXICITY DATABASES
Citation:
Richard, A M., J. M. Burch, AND C. R. Williams. DSSTOX: NEW ON-LINE RESOURCE FOR PUBLISHING AND INTEGRATING STANDARDIZED STRUCTURE-INCLUSIVE TOXICITY DATABASES. Presented at ADMET-1, San Diego, California, Feb 11-13, 2004.
Description:
DSSTox: New On-line Resource for Publishing Structure-Standardized Toxicity Databases
Ann M Richard1, Jamie Burch2, ClarLynda Williams3
1Nat. Health and Environ. Effects Res. Lb, US EP& Ret Triangle Park, NC 27711; 2EPA-NC
Central Univ Student COOP, US EPA, lies. Triangle Park, NC 27711; 3NC State Univ., Dept. of
Bioinformatics, Raleigh, NC 27695
A major impediment to the development of improved in silico toxicity prediction eapabilities and greater participation of chemists in exploring structure-activity relationships (SAR) in toxicology is the lack of chemical structure annotation to much of the historical public toxicity information. Chemical structures, and the chemistry underlying toxicity in biological systems, provide a natural common metric for SAR exploration of these diverse data as well as for linking these data more broadly to the data being generated in the emerging ?omics fields. The DSSTox (Distributed Structure-Searchable Toxicity) data network is a new public initiative whose objectives are to: 1) promote a standard SDF format and minima! level of chemical structure annotation to public toxicity data; 2) provide a central website registry thr publishing and making these data ifies accessible to all; and 3) involve the toxicological experts and sources most familiar with these data in providing minimal description and documentation for these datasets. On public launch, the DSSTox central website will offer 4 public toxicity databases in structure-standardized format, along with a range of information resources and tools for community adoption and propagation of database publication standards
This abstract does not represent EPA policy.