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HARMONIZATION OF RISK ASSESSMENT: DISRUPTION OF INTRACELLULAR SIGNALING AS A COMMON MODE OF ACTION FOR ENVIRONMENTAL
Impact/Purpose:
In order to harmonize the risk assessment process, information is needed regarding application of mechanistic data for diverse family of chemicals. The information about mechanism or mode of action offers a sound basis for risk assessment decisions. The goal of this project is identify intracellular signaling pathways critical for the expression of adverse effects following chemical exposure. The research will (a) identify critical intracellular signaling event for the adverse effect of diverse chemicals; (b) disruption of intracellular signaling lead to an adverse effect in vitro and in vivo; (c) in vitro models can be used to demonstrate the chemical effects in vivo. This project will provide an example of how data on common mode of action can be used for risk assessment. In addition, the in vitro models that are developed based on mode of action can be used for screening untested/new chemicals of environmental concern.