Impact/Purpose:

Local microscopic dose will be the key for linking particle exposure to toxic mechanisms. The computational fluid and particle dynamics (CFPD) modeling is the only way to obtain the microscopic dose at the tissue levels. This study will provide the micro scale dosimetry data that can help understand potential mechanisms of particulate matter (PM) toxicity and to improve the health risk assessment. The results will be related to all aspects of PM studies. Specifically, this work will support efforts to (1) Develop a comprehensive dosimetry model including susceptible population and (2) Link specific close information to mechanisms of PM toxicity at local tissue levels.

Description:

The aim of this project is to develop three-dimensional computer simulations for aerosol transport and deposition in human respiratory tract. Three-dimensional CFPD (computational fluid and particle dynamics) modeling is a powerful tool to obtain microscopic dose information at local anatomic sites within the respiratory tract. Detailed flow patterns and particle trajectories and resulting deposition sites have been analyzed for some nanoparticles and micron particles in the oropharyngeal as well as tracheobronchial airway models. The study will continue to simulate particle deposition in the small airways and alveolar region and eventually to simulate the respiratory flow and particle deposition in the entire lung as the way we breathe. Visualization of the entire process and complete charting of deposition pattern throughout the respiratory tract will be pursued.

Record Details: