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INTERPRETING SPONTANEOUS RENAL LESIONS IN SAFETY AND RISK ASSESSMENT
Citation:
Wolf, D C. INTERPRETING SPONTANEOUS RENAL LESIONS IN SAFETY AND RISK ASSESSMENT. Presented at American College of Veterinary Pathologist Annual Meeting, Banff, Canada, 11/16-19/03.
Description:
Interpreting Spontaneous Renal Lesions in Safety and Risk Assessment
Douglas C. Wolf, D.V.M., Ph.D.
Introduction
Risk assessment is a process whereby the potential adverse health effects from exposure to a xenobiotic are predicted after evaluation of the available information on the biological impact of exposure to the agent. The morphologic changes identified histologically that occur after treatment are a major component of this evaluation and on which the risk assessment is frequently based. In many cases the compound in question may cause unique lesions which can be readily indentified, however, much of the time the test chemical enhances the development of spontaneous lesions which, in many cases, makes accurate evaluation of toxicity difficult. The present abstract and associated presentation will attempt to show how exacerbation of spontaneous lesions and separation of toxic response from background disease is incorporated into the hazard assessment component of risk characterization.