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ORGANIC SYNTHESES USING MICROWAVES AND SUPPORTED REAGENTS
Citation:
Varma*, R S. ORGANIC SYNTHESES USING MICROWAVES AND SUPPORTED REAGENTS. Chapter 6, Loupy, A. (ed.), Microwaves in Organic Synthesis, ISBN 3-527-30514-9. Wiley-VCH, Weinheim, Germany, , 181-218, (2002).
Description:
Microwave-accelerated chemical syntheses under solvent-free conditions have witnessed an explosive growth. The technique has found widespread application predominantly exploiting the inexpensive unmodified household microwave (MW) ovens although the use of dedicated MW equipment has been rapidly gaining ground. This environmentally friendlier solvent-free approach often involves exposure of neat reactants to MW irradiation or employs supported reagents on recyclable inorganic oxides or catalysts and has been adequately demonstrated in several MW-assisted condensation, deprotection, rearrangement, cyclization, reduction and oxidation reactions. The rapid one-pot preparation of heterocyclic compounds from in situ generated reactive intermediates and the general application to multi-component reactions, that are adaptable for building a library of compounds has been accomplished using this MW technique. More recently, the strategy has been extended to combinatorial chemistry and the synthesis of a newer class of solvents, ionic liquids that are essentially molten salts with barely measurable vapor pressure. The chapter also includes sections on organometallic chemistry, radiolabeling and enzyme-catalyzed reactions that are enhanced by microwave irradition.