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ASSESSMENT OF MALE REPRODUCTIVE TOXICITY
Citation:
Clegg, E. D., S D. PERREAULT, AND G R. Klinefelter. ASSESSMENT OF MALE REPRODUCTIVE TOXICITY. Fourth, Chapter 28, A.W. Hayes (ed.), Principles and Methods in Toxicology. Taylor & Francis, Inc., Philadelphia, PA, , 1263-1300, (2001).
Description:
This chapter reviews the subject of risk assessment in male reproductive toxicology. After providing an overview of the risk assessment process, laboratory test protocols, including those specified by EPA and used by NIEHS are summarized and discussed in detail with respect to their advantages and limitations. Endpoints currently used in these test protocols are reviewed, and new endpoints that may be useful in mechanistic studies are presented. The chapter also highlights in vitro approaches for evaluating reproductive cells and tissues as well as new and promising biomarkers of male reproductive effects and their predictive power with respect to male fertility. Finally, factors important for risk characterization, such as structure activity relationships, pharmacokinetics and reversibility of effects are discussed with respect to assessing male reproductive risks. This chapter is intended as an instructional text for students in toxicology programs and a reference for reproductive toxicologists and risk assessors.