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NTP CENTER FOR THE EVALUATION OF RISKS TO HUMAN REPRODUCTION: PHTHALATES EXPERT PANEL REPORT ON THE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF BUTYL BENZYL PHTHALATE
Citation:
Kavlock, R J., K. Boekelheide, R. E. Chapin, M. Cunningham, E. Faustman, P. M. Foster, M. Golub, R. Henderson, I. Hinberg, R. Little, J. G. Seed, K. Shea, S. Tabacova, R. Tyl, P. Williams, AND T. Zacharewski. NTP CENTER FOR THE EVALUATION OF RISKS TO HUMAN REPRODUCTION: PHTHALATES EXPERT PANEL REPORT ON THE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF BUTYL BENZYL PHTHALATE. REPRODUCTIVE TOXICOLOGY. Elsevier Science BV, Amsterdam, Netherlands, 16(5):453-487, (2002).
Description:
The phthalates are a family of environmentally important compounds with diverse uses. Reproductive toxicity has been demonstrated for some members of this family. The NTP Center for the Evaluation of Risk to Human Reproduction (CERHR) convened an expert panel charged with examining and reporting on the reproductive and developmental toxicity of six different phthalates: di(2-ethylhexyl) phthalate, di-isodecyl phthalate, di-isononyl phthalate, di-n-octyl phthalate, butyl benzyl phthalate, and di-n-hexyl phthalate. Reported here are the findings of the panel which includes detailed descriptions of the chemistry, exposure, usage, and reported toxicity of each compound, with special attention to reproductive and developmental toxicity. Data from current related research efforts are provided, and a critical evaluation of the toxicity of each compound is presented.