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DEVELOPMENTAL TOXICITY OF METHOPRENE AND SEVERAL DEGRADATION PRODUCTS IN XENOPUS LAEVIS
Citation:
Degitz, S J., E J. Durhan, J E. Tietge, P A. Kosian, G W. Holcombe, AND G T. Ankley. DEVELOPMENTAL TOXICITY OF METHOPRENE AND SEVERAL DEGRADATION PRODUCTS IN XENOPUS LAEVIS. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 64:97-105, (2003).
Description:
Methoprene is an insect juvenile growth hormone mimic, which inhibits pupatation and is used for the control of emergent insect pests such as mosquitoes. Researchers have hypothesized that methoprense use in the US may be a contributing factor to the recent increase in malformed amphibians. However, little is known concerning the developmental toxicity of methoprene and several degradation products in amphibians. Assays were conducted under static renewal (24 h) conditions and chemical concentrations in water were measured at the beginning and end of the renewal periods. - - - Concerns for methoprene-mediated developmental toxicity to amphibians may be unwarranted.