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ELEVATION OF SERUM 17-B-ESTRADIOL IN CHANNEL CATFISH FOLLOWING INJECTION OF 17-B-ESTRADIOL, ETHYNYL ESTRADIOL, ESTRONE, ESTRIOL, AND ESTRADIOL-17B- GLUCURONIDE
Citation:
Tilton, F., W H. Benson, AND D. K. Schlenk. ELEVATION OF SERUM 17-B-ESTRADIOL IN CHANNEL CATFISH FOLLOWING INJECTION OF 17-B-ESTRADIOL, ETHYNYL ESTRADIOL, ESTRONE, ESTRIOL, AND ESTRADIOL-17B- GLUCURONIDE. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 9(4):169-172, (2001).
Description:
17-b-Estradiol is naturally converted in numerous organisms to various derivatives/metabolites, which may be excreted from the organism into its immediate external environment. There is a paucity of data regarding the biological effects of the derivatives/metabolites on aquatic organisms. Male channel catfish (200-500g, N = 5, 12-18 months) were injected with 1 mg/kg 17-b-estradiol (E2), ethynyl estradiol (EE2), estrone, estriol or E2-17-b-glucuronide with subsequent measurements of vitellogenin (Vtg) and serum E2 concentrations 7 days post injection. EE2 and E2 gave the largest magnitude of Vtg response followed by estrone and estriol. Exposure to EE2, estrone, and E2-17-b-glucuronide all induced significant increases in serum E2 concentrations. This study indicates that metabolites of E2 are also estrogenic and may potentially disrupt estrogen feedback loops within aquatic organisms.