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SOLVENT-FREE ACCELERATED ORGANIC SYNTHESES USING MICROWAVES
Citation:
Varma*, R S. SOLVENT-FREE ACCELERATED ORGANIC SYNTHESES USING MICROWAVES. Senzel, A.J. (ed.), PURE AND APPLIED CHEMISTRY. IUPAC, 73(1):193-198, (2001).
Description:
Abstract: A solvent-free approach for organic synthesis is described which involves microwave (MW) exposure of neat reactants (undiluted) either in presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or 'doped' surfaces, namely, Fe(NO3)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH2OH-clay, PhI(OAc)2-alumina, NaIO4-silica, MnO2-silica, and NaBH4-clay. A variety of deprotection, condensation, cyclization, oxidation and reduction reactions will be presented including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and a-tosyloxyketones. The application of this solventless MW approach to multi-component reactions will be highlighted that can be adapted for high speed parallel synthesis of the library of dihydropyrimidine-2(1H)-ones and imidazo[1,2-a]annulated pyridines, pyrazines and pyrimidines.