Citation:

Kappe, C. O. AND R S. Varma*. A NOVEL HIGH-SPEED METHOD FOR THE GENERATION OF 4-ARYLDIHYDROPYRIMIDINE COMPOUND LIBRARIES USING A MICROWAVE-ASSISTED BIGINELLI CONDENSATION PROTOCOL -. Third International Electronic Conference on Synthetic Organic Chemistry, Internet, 9/1-30/1999.

Description:

In this presentation we report the application of microwave assisted chemistry to the parallel synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones employing a solventless Biginelli multicomponent condensation protocol. The novel method employs neat mixtures of B-ketoesters, aryl aldehydes, and urea derivatives with polyphosphate ester (PPE) being used as reaction mediator. Irradiation of these mixtures for 90 s in an unmodified household microwave oven provides dihydropyrimidones in 61-95% yield after aqueous work-up. This protocol was extended towards the parellel synthesis of DHPM compound libraries.

Record Details:

Record Type:DOCUMENT( PRESENTATION/ PAPER)

Product Published Date:09/19/1999

Record Last Revised:06/21/2006

Record ID: 63821

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Related Organizations:

Role :OWNER

Organization Name :US ENVIRONMENTAL PROTECTION AGENCY

Organization Name :OFFICE OF RESEARCH AND DEVELOPMENT

Organization Name :NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

Organization Name :SUSTAINABLE TECHNOLOGY DIVISION

Document IDs:

EPA Number :EPA/600/A-01/030