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ALTERNATIVE EXPOSURE MEASUREMENT DESIGNS TO IMPROVE EPIDEMIOLOGICAL STUDY DESIGNS: DETERMINANTS OF TEMPORAL VARIABILITY IN ENVIRONMENTAL CONCENTRATIONS, EXPOSURES, AND BIOMARKERS
Citation:
Egeghy, P P., J J. Quackenboss, A H. Ozkaynak, AND P. B. Ryan. ALTERNATIVE EXPOSURE MEASUREMENT DESIGNS TO IMPROVE EPIDEMIOLOGICAL STUDY DESIGNS: DETERMINANTS OF TEMPORAL VARIABILITY IN ENVIRONMENTAL CONCENTRATIONS, EXPOSURES, AND BIOMARKERS. Presented at National Children's Study Meetings, Baltimore, MD, December 17-18, 2002.
Impact/Purpose:
The overall objective of the NERL NCS Pilot Project is to investigate optimal approaches for the exposure measurements needed to support the planned Interagency National Children's Study. The objective of this task is to increase the scientific effectiveness of epidemiologic designs while minimizing costs by addressing exposure misclassification.
Description:
The National Human Exposure Assessment Survey in Maryland (NHEXAS-MD) was a longitudinal study of multimedia exposure to metals, pesticides, and polycyclic aromatic compounds (PAHs). Measurements were made and questionnaires were concurrently administered to identify sources of exposure and to identify activities associated with elevated exposures. This project aims to identify significant determinants of the temporal variability identified in previous analyses and to examine the utility of available exposure assessment approaches in the context of this variability. Specifically, the relationship between relatively long-term estimates of exposures and time-varying explanatory factors related to the environment and to the study participants' activity patterns, diet, other personal attributes (as recorded in questionnaires and diaries) will be examined. The effectiveness of the various exposure assessment approaches, both individually and in combination, will be evaluated.
This work has been funded wholly or in part by the United States Environmental Protection Agency. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.