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USING THE HASSE DIAGRAM TECHNIQUE TO PRIORITIZE POTENTIAL PBTS
Citation:
Carlsen, L., J. D. Walker, O. G. Mekenyan, AND C L. Russom. USING THE HASSE DIAGRAM TECHNIQUE TO PRIORITIZE POTENTIAL PBTS. Presented at 5th Hasse Workshop 2002. Integrated Environmental Analysis, National Environmental Research Institute, Roskilde, Denmark, November 24-25, 2002.
Description:
The identification of chemicals with PBT (Persistence, Bioaccumulation,Toxicity) potential is of major interest to many organizations. In the present study about 2800 commercially important chemicals are included.
Initially Hasse Diagram Technique (HDT) has been applied to create an event space allowing grouping the chemicals according to the biodegradation and persistence in the aquatic environment. Thus, Hasse Diagram Technique will be used to prioritize chemicals with predicted bioconcentration factors (BCFs) > 5,000, biodegradation half-lives > 6 months, Henry's Law Constants < 10-2 atm m3/mole, hydrolysis half-lives > 30 days and fish acute LC50 values < 1/mg/L. Quantitative Structure Activity Relationship models will be used tmake the predictions. Alternatively chemicals with 5000 > BCF > 2000, Biodegradation half-lives between 2 and 6 months will be studied analogously.
This presentation with describe how the Hasse Diagram Technique will be used to prioritize potential PBTs.