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DETERMINATION OF IN VIVO AND IN VITRO CHEMICAL PARTITION COEFFICIENTS IN FISH TISSUES FOR USE IN PHYSIOLOGICALLY BASED TOXICOKINETIC MODELLING
Citation:
Hoffman, A D. AND S. L. Bertlesen. DETERMINATION OF IN VIVO AND IN VITRO CHEMICAL PARTITION COEFFICIENTS IN FISH TISSUES FOR USE IN PHYSIOLOGICALLY BASED TOXICOKINETIC MODELLING. Presented at 6th Annual Sigma Xi Scientific Poster Exhibition, University of Minnesota-Duluth School of Medicine Atrium, Duluth, MN, February 20-23, 1990.
Description:
The development of physiologically based toxicokinetic (PB-TK) models has precipitated a need for accurate and rapid estimates of chemical partition coefficients to parameterize these models. In vitro tissue:blood and blood:water partition coefficents were determined for a homologous series of chlorinated ethanes using a gas equilibration method. These values were then used to parameterize a physiologically based toxicokinetic model for the uptake and disposition of chloroethanes by fish. In vivo partition coefficients were determined by analysis of tissue residues from fish that had reached or were near steady-state in the blood during a sub-lethal exposure. The comparison of in vitro and in vivo chemical partitioning information provides a basis for evaluation of these models. This abstract does not necessarily reflect EPA policy.