You are here:
MYOCARDIAL INJURY FROM INHALED COMBUSTION PARTICLES: IS THERE A ROLE FOR ZINC?
Citation:
Kodavanti, U P., C. F. Moyer, M. Schladweiler, A. D. Ledbetter, P. S. Gilmour, R. Hauser, D. C. Christiani, D L. Costa, AND A. Nyska. MYOCARDIAL INJURY FROM INHALED COMBUSTION PARTICLES: IS THERE A ROLE FOR ZINC? Presented at American Thoracic Society, Seattle, WA, May 16-21, 2003.
Description:
Myocardial injury from inhaled combustion particles: Is there a role for zinc?
U.P.Kodavanti, PhD 1, C.F.Moyer, PhD, DVM 2, A.D.Ledbetter, BS 1, M.C.Schladweiler, BS
1, P.S.Gilmour, PhD 1, R.Hauser, ScD, MPH 3, D.C.Christiani, MPH, MS 3, D.L.Costa, ScD
1 and A.Nyska, PhD 4. 1ETD, NHEERL, ORD, US EPA, RTP, NC; 2Pathology Associates,
Raleigh, NC; 3Harvard School of Public Health, Boston, MA and 4NIEHS, RTP, NC.
Although cardiovascular morbidity and mortality have been associated with ambient
particulate matter (PM), causality has not been established. Moreover, causative
constituents for cardiovascular injury have not been identified. It has been hypothesized
that a combination of unique exposure conditions, rat strains and PM composition would
result in cardiac injury. To address this, a retrospective analysis was conducted in which
hearts from rats exposed by inhalation to combustion and ambient PM were evaluated
histologically. Of 4 studies examined, 1 provided evidence of cardiac pathology. This study
involved nose-only exposure of male Sprague Dawley (SD), Wistar Kyoto (WKY) and
Spontaneously Hypertensive (SH) rats to emission source particles (EPM) containing
leachable zinc (14.5 microgram/mg), at 10 mg/m3, 6h/dx4d or 1d/wkx4 or 16 wks. Five of 6
WKY exposed to EPM for 16 wks demonstrated cardiac lesions. To characterize
EPM-associated lesions in WKY rats, a variety of special stains were employed.
Decreased granulated mast cells, multifocal myocardial degeneration, chronic-active
inflammation, and fibrosis were present in EPM-exposed WKY rats. None of these lesions
were present in air-exposed WKY rats. EPM-related cardiac lesions were not present in
SD and SH rats. Cardiac injury was apparent in the absence of prominent lung lesions
and was specific to WKY with long-term inhalation of EPM. The role of zinc in cardiac injury
is being investigated. In summary, we provide evidence of cardiac injury from inhalation of
environmentally relevant PM with leachable zinc, and support the epidemiological
associations. (Does not reflect US EPA policy).
Funded By: USEPA and NIEHS
Off-Label Use Disclosure: No
Financial Disclosure: No