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CORRELATED PULMONARY AND SYSTEMIC EFFECTS IN SPONTANEOUSLY HYPERTENSIVE RATS FOLLOWING ACUTE EXPOSURES TO CONCENTRATED AMBIENT PARTICLES (CAPS)
Citation:
Schladweiler, M., A. D. Ledbetter, L. Walsh, E. R. Lappi, H. Hilliard, M I. Gilmour, D L. Costa, J. Norwood, K Crissman, G. E. Hatch, J H. Richards, AND U P. Kodavanti. CORRELATED PULMONARY AND SYSTEMIC EFFECTS IN SPONTANEOUSLY HYPERTENSIVE RATS FOLLOWING ACUTE EXPOSURES TO CONCENTRATED AMBIENT PARTICLES (CAPS). Presented at Society of Toxicology, Nashville, TN, March 17-21, 2002.
Description:
The increase in plasma fibrinogen, a risk factor for cardiovascular disease (CVD), has recently been associated with exposures to particulate air pollution (PM) in humans. We have shown a similar pattern of fibrinogen increases in rats exposed to emission PM. The purpose of this study was to ascertain the consistency of the plasma fibrinogen increase following acute CAPS exposures, and its relationship to lung injury in a rat model of CVD. Male Spontaneously Hypertensive (SH) rats (13 wks) were exposed whole body to filtered air (n=4-7) or CAPS (n=5-9) from local air, 4 h/d x 1 d (6 replicates) or 2 d (2 replicates). The estimated daily CAPS concentrations ranged from 700-1800 g/m3. To