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PROGRAM FOR THE IDENTIFICATION AND REPLACEMENT OF ENDOCRINE DISRUPTING CHEMICALS
Citation:
Young*, D. PROGRAM FOR THE IDENTIFICATION AND REPLACEMENT OF ENDOCRINE DISRUPTING CHEMICALS. Presented at Workshop on Effective Risk Management of Endocrine Disrupting Chemicals, Cincinnati, OH, 9/18-19/2001.
Description:
A computer software program is being developed to aid in the identification and replacement of endocrine disrupting chemicals (EDC). This program will be comprised of two distinct areas of research: identification of potential EDC nd suggstions for replacing those potential EDC. This identification portion of the program will be accomplished by constructing virtual 3-D representations of potential EDC and then comparing these representations to a library of known EDC and to a library of chemicals that have been identified not to be an EDC. These libraries will most likely focus around the estrogen receptor sites since this is where a vast majority of the data is. This identificaton portion of the research will be conducted external to the USEPA. The second phase of the program will focus on suggesting replacements. This portion of the program will suggest a series of possible replacements for potential EDC. The suggested replacements will be a chemical or a mixture of chemicals that will best match the appropriate chemical and physical properties of the EDC. The portion of the program will be configured similar to the software program PARIS II (Program for Assisting the Replacement of Industrial Solvents), which was developed within the USEPA. This project to identify and replace EDC is scheduled to begin in the Fall of 2001. This presentation will introduce a detailed plan for this project.