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ISSUES IN DEVELOPING A TWO-GENERATION AVIAN TOXICITY TEST WITH JAPANESE QUAIL
Citation:
Bennett, R S., J. E. Brugger*, A Fairbrother, A. Leopold, N. Mastrota, AND M. A. Ottinger. ISSUES IN DEVELOPING A TWO-GENERATION AVIAN TOXICITY TEST WITH JAPANESE QUAIL. Presented at 22nd Annual SETAC Meeting, Baltimore, MD, November 11-15, 2001.
Description:
As a subgroup of the OECD Expert Group on Assessment of Endocrine Disrupting Effects in Birds, we reviewed unresolved methodological issures important for the development of a two-generation toxicity test, discussed advantages and disadvantages of alternative approaches, and proposed several tests for resolving these issues during the pre-validation phase of this process. The overall objective of the test should be to characterize endocrine and other toxic effects on the development and reproduction of birds over two generations. Several experimental design issues will be discussed, including: 1) the timing and duration of dietary exposure over two generations, 2) the suite of fitness and endocrine-related endpoints to be used and how they are interrelated, 3) the use of hypothesis testing to determine NOAELs vs defining dose-response relationships, 4) methods for selection of F1 chicks for the breeding populations, and 5) the use of a constant dietary concentration for all life stages or a constant dietary concentration for all life stages or a constant ingested dose.