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INTERSPECIES DOSIMETRY MODELS FOR PULMONARY PHARMACOLOGY
Citation:
Martonen, T B., J. D. Schroeter, AND J. S. Fleming. INTERSPECIES DOSIMETRY MODELS FOR PULMONARY PHARMACOLOGY. Presented at XIVth World Congress of Pharmacology, San Francisco, CA, July 7-12, 2002.
Description:
Interspecies Dosimetry Models for Pulmonary Pharmacology
Ted B. Martonen, Jeffry D. Schroeter, and John S. Fleming
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, and, Division of Pulmonary Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC 27514; Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC 27599; Southampton General Hospital, Southampton, UK
Inhalation exposures tests with surrogate animals can be performed to estimate the therapeutic effects of pharmacologic drugs. However, it is difficult to extrapolate the findings of animal tests to human conditions. In this work, interspecies dosimetry models especially designed for implementation with pharmaceutical protocols are presented. The mathematical model was tested with data from surrogate (rat) simulations, and theoretical predictions agreed well with experimental particle deposition measurements. For human subjects, appropriate algorithms for morphologies and ventilatory parameters were used as subroutines in the validated model. We conducted a comprehensive series of interspecies computer simulations describing the behavior of inhaled aerosols. By a priori determining the laboratory conditions necessary for animals tests to accurately mimic human conditions, the use of interspecies models is very cost effective. We propose, therefore, that models be actively integrated into pulmonary pharmacology studies.
Disclaimer: This is an abstract of a proposed presentation and does not necessarily reflect EPA policy.