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ROLE OF MONOCYTES IN RESPIRATORY SYNCTIAL VIRUS (RSV) INFECTION.
Citation:
Becker, S E. AND J M. Soukup. ROLE OF MONOCYTES IN RESPIRATORY SYNCTIAL VIRUS (RSV) INFECTION. Presented at American Thoracic Society, Atlanta, GA, March 17-22, 2002.
Description:
ROLE OF MONOCYTES IN RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION.
Joleen M. Soukup and Susanne Becker, National Health and Environmental Effects Research
Laboratory, US EPA, Research Traingle Park, NC USA.
RSV infection in airway epithelial cells (EC) results in production of the chemokines RANTES
and MIP-1", and leukocyte differentiation factors G-CSF and GM-CSF. These products attract
monocytes (Monos) to the site of infection and may influence their function and differentiation.
In the present study, employing immuno-fluorescence techniques, Monos in co-cultures with
infected EC are found to inhibit viral replication, as well as spread of RSV to uninfected cells.
They also inhibit the production of RANTES, G-CSF and GM-CSF. Furthermore, Monos
show an RSV dose dependent increase in the expression of surface receptors involved in
dendritic cell maturation including CD40, CD80, CD86 and HLA-DR, and produce IL-1,
TNF and IL-6. These results suggest that Monos at the site of RSV infection, play an
important role both in confining infection and in the development of immune responses to RSV.