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TOXICITY EVALUATION OF 1,3,5-TRINITROBENZENE (TNB) IN SHREWS (CRYPTOTIS PARVA)
Citation:
Reddy, T V., F B. Daniel, G. R. Olson, B E. Wiechman, AND G. Reddy. TOXICITY EVALUATION OF 1,3,5-TRINITROBENZENE (TNB) IN SHREWS (CRYPTOTIS PARVA). Presented at Society of Toxicology, Philadelphia, PA, March 17-24, 2000.
Description:
TNB has been detected as an environmental contaminant of soil and water at certain Army installations and production waste disposal sites. At present there are no toxicity data on TNB in small wild mammals that might be used for ecological risk assessment. Therefore, a 14-day toxicity study was conducted to determine the No Observed Adverse Effect Level (NOAEL) of TNB in the least shrew (Cryptotis parva). Male and female shrews (10/group/sex) were fed a mixture of wet-dry Purina Cat Chow containing 0, 5, 10, 20 and 40 pm TNB for 14 days. The calculated average consumed doses were 0, 10.68, 22.24, 37l79 and 98.27 mg/kg/day for males and 0, 10.75, 21.60, 45.26 and 98.72 mg/kg/day for females. There were no significant differences in food and water consumption among the groups. However, there was a decrease in body weight in males (10 ot 40 ppm) and a significant increase in body weight in females in the 20 ppm dose group. The relative spleen weights were increased in females (10 to 40 ppm). There were no significant changes in hematology parameters in females, while in males there was a significant decrease in RBC and an increase in WBC in the 40 ppm dose group. One histopathological change was erythroid cell hyperplasia in the spleen of males receivig 20 and 40 ppm TNB diet. The NOAEL for male and female shrews was determined as 10.75 mg TNB kg/day for the 14-day study.