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SOLVENT-FREE ORGANIC SYNTHESES USING MICROWAVES
Citation:
Varma*, R S. SOLVENT-FREE ORGANIC SYNTHESES USING MICROWAVES. Presented at International Conference on Microwave Chemistry, Antibes, France, 09/4-7/2000.
Description:
The latest results on microwave-expedited solvent-free approach as applied to the assembly of organic molecules will be presented. The salient features of this expeditious methodology such as solvent conservation and ease of manipulation etc. will be described in the context of routine laboratory experiments which emphasizes the use of the relatively benign catalysts or reagents supported on the surfaces of recyclable mineral oxide(s) such as alumina, silica and clay. The technique will be discussed for the useful organic conversions namely deprotection, condensation, oxidation, reduction and cyclization reactions. The elaboration of in situ generated intermediates in one-pot synthesis of parmacologically significant heterocycles will be presented that can be adapted for the rapid parallel synthesis and building libraries of such compounds.