You are here:
REPRODUCTIVE AND PHYSIOLOGICAL EFFECTS OF AQUATIC EXPOSURE TO TRENBOLONE, AN ENVIRONMENTAL ANDROGEN
Citation:
Peterson, B. N., C. F. Foran, AND W H. Benson. REPRODUCTIVE AND PHYSIOLOGICAL EFFECTS OF AQUATIC EXPOSURE TO TRENBOLONE, AN ENVIRONMENTAL ANDROGEN. Presented at SETAC 22 Annual Meeting, Baltimore, MD, November 11-15,2001.
Description:
Reproductive and Physiological Effects of Aquatic Exposure to Trenbolone, an Environmental Androgen (Abstract). To be presented at the 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry: Changing Environmental Awareness: Societal Concerns and Scientific Responses, 11-15 November 2001, Baltimore, MD. 1 p. (ERL,GB R856).
Trenbolone, an androgenic feed additive, represents a likely source of environmental androgens for fish exposed to run-off from cattle feed lots. The purpose of this study was to evaluate the potenital of trenbolone to alter reproduction and characterize endpoints related to endocrine function as biomarkers for impairment. Reproductively active pairs of adult Japanese medaka were aqueously exposed to trenbolone for 14 days at concentrations ranging from 2 ng/L. Egg production was significantly impaired at higher doses of trenbolone,
but egg size, fertilization rate and hatching success were not affected. Trenbolone inhibited the production of vitellogenin in the liver of females in a concentration-dependent manner and increased the size of testis in males exposed to 2000 ng/L. Trenbolone, at higher concentrations, has the potential to be a reproductive toxicant by inhibiting the production of vitellogenin and subsequently influencing fecundity.