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TRANSGENERATIONAL EXPOSURE TO TRENBOLONE IN JAPANESE MEDAKA: IN OVO VERSUS HATCHLING EXPOSURE SETAC 22 ANNUAL MEETING, BALTIMORE, MD NOVEMBER 11-15, 2001
Citation:
Foran, C M., B. N. Peterson, AND W H. Benson. TRANSGENERATIONAL EXPOSURE TO TRENBOLONE IN JAPANESE MEDAKA: IN OVO VERSUS HATCHLING EXPOSURE SETAC 22 ANNUAL MEETING, BALTIMORE, MD NOVEMBER 11-15, 2001. Presented at SETAC 22 Annual Meeting, Baltimore, MD, Nov. 11-15, 2001.
Description:
. Transgenerational Exposure to Trenbolone in Japanese Medaka: In Ovo Versus Hatchling Exposure (Abstract). To be presented at the 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry: Changing Environmental Awareness: Societal Concerns and Scientific Responses, 11-15 November 2001, Baltimore, MD. 1 p. (ERL,GB R857).
Though environmental estrogens have been receiving much attention, several endocrine active substances are likely to act as androgens. Trenbolone is an androgenic additive found in cattle feed, and has the potential to be a component in run off from cattle farms. This study focuses on the reproductive and physiological effects of trenbolone when exposure occurs early in development. Effects on offspring producted by adult pairs exposed for two weeks to trenbolone were compared to similar results for animals exposed as hatchlings. With a range
of exposure from 2 ng/L to 2000 ng/L, growth of the exposed animals and a condition factor (g/mm) was not affected. At the highest concentration, the resulting sex ratio for both exposure groups was male biased, although the skew in sex ratio was significant only for exposed hatchlings (n = 97; X2 = 30.3, p < 0.001) and not in ovo exposed animals (n = 9). In addition to effects of growth and differentiation, the reproductive potential and endocrine function of each group will be compared in adult animals.