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PROGRESS REPORT ON THE DSSTOX DATABASE NETWORK: NEWLY LAUNCHED WEBSITE, APPLICATIONS, FUTURE PLANS
Citation:
Richard, A. M. AND C. R. Williams. PROGRESS REPORT ON THE DSSTOX DATABASE NETWORK: NEWLY LAUNCHED WEBSITE, APPLICATIONS, FUTURE PLANS. Presented at 2003 SOT Annual Mtg."Innovation in Toxicological Sciences", Salt Lake Sity, Utah, 03/9-13/03.
Description:
Progress Report on the DSSTox Database Network: Newly Launched Website, Applications, Future Plans
Progress will be reported on development of the Distributed Structure-Searchable Toxicity (DSSTox) Database Network and the newly launched public website that coordinates and serves as the central hub for this effort. DSSTox is an EPA-sponsored, community-wide project whose goals are to: 1) create and promote the use of standard format, chemical structure-inclusive data files for storing public chemical toxicity data; 2) involve the international user community in the effort to migrate more public toxicity data into the standard format for sharing; and 3) facilitate structure-searchability across toxicity databases and more complete access to data for use in toxicity prediction model development. DSSTox toxicity data files for a variety of public toxicity databases have been created for carcinogenicity, mutagenicity, aquatic toxicity, pesticide toxicity, and estrogen-receptor binding; a variety of other database files are in development. Importing of these files into commercial chemical relational database applications and other public web-based applications provide sophisticated structure-searching capability for exploring the structural basis for toxicity across multiple types of biological endpoints. Essential to the ultimate success of this effort will be community involvement in propagating the proposed data standards and hosting DSSTox standard format data files. Hence, one of the most important roles of the central DSSTox website is that of enlisting and coordinating the efforts of the larger toxicology and modeling communities in contributing to this public database project.
This abstract does not reflect EPA policy.