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ACUTE NEUROTOXIC EFFECTS OF INHALED PERCHLOROETHYLENE ON PATTERN VISUAL EVOKED POTENTIALS AS A FUNCTION OF EXPOSURE AND ESTIMATED BLOOD AND BRAIN CONCENTRATION.
Citation:
Bercegeay, M, E M. Kenyon, AND W K. Boyes. ACUTE NEUROTOXIC EFFECTS OF INHALED PERCHLOROETHYLENE ON PATTERN VISUAL EVOKED POTENTIALS AS A FUNCTION OF EXPOSURE AND ESTIMATED BLOOD AND BRAIN CONCENTRATION. Presented at Society of Toxicology 42nd Annual Meeting, Salt Lake City, UT, March 9-13, 2003.
Description:
Previous experiments have shown the effects of acute inhalation exposure to trichloroethylene (TCE) and toluene are related to the target tissue concentration at the time of testing. The current studies examined exposure to another volatile organic compound, perchloroethylene (PERC), for comparison to the other solvents. A physiologically-based pharmacokinetic (PBPK) model was developed for ad-lib fed (350-450 g) adult male Long-Evans rats. Rats were exposed by inhalation to 0, 1,000, 2,000, 3,000, or 4,000 ppm PERC and tested at exposure durations (including 0.5, 1, 1.5 or 2 hr) yielding C x t products up to 4000 ppm-hr. Exposure conditions yielding C x t products greater than 4000 ppm-hr were not tested. Steady-state pattern-elicited visual evoked potentials were recorded during exposure sessions. The pattern stimulus was a 0.16 cpd vertical sinusoidal grating with a contrast of either 60% or 0% ("noise" evaluation), that was modulated in an appearance / disappearance mode at 5 Hz. Exposure to PERC reduced the amplitude of the frequency-double spectral component (F2) at all air concentrations tested, including those projected to produce concentrations as low as 17.7 mg/l in blood and 97.1 mg/l in brain (1000 ppm for 0.5 hr). The actions of PERC were qualitatively similar to those measured previously for toluene and TCE. (This abstract does not necessarily reflect EPA policy).