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MICROWAVE-ACCELERATED MULTICOMPONENT REACTIONS UNDER SOLVENT-FREE CONDITIONS
Citation:
Varma*, R S. MICROWAVE-ACCELERATED MULTICOMPONENT REACTIONS UNDER SOLVENT-FREE CONDITIONS. Presented at American Chemical Society (Central Regional Meeting), Covington, KY, 5/16-19/2000.
Description:
The application of microwave-accelerated solventless synthetic protocols in multicomponent (MCC) reactions will be exemplified by several condensation and cyclization reactions including the rapid one-pot assembly of valuable heterocyclic compounds from in situ generated intermediates. A rapid assembly of imidazo [1,2-a] annulated pyridines, pyrazines and pyrimidines will be described that occurs in the presence of montomorillonite K 10 cly. Recent developments of microwave-assisted chemistry in the parallel synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones employing a solventless Biginelli multicomponent condensation protocol willl also be presented. This novel method, extendible to the parallel synthesis of DHPM ccompound libraries, employs neat mixtures of $-ketoesters, arylaldehydes, and urea derivatives in the presence of polyphosphate ester (PPE) and provides good yield dihydropyrimidones in less then two(2) minutes using an unmodified household microwave oven.